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KMID : 0352719920160020093
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Journal of Ginseng Research
1992 Volume.16 No. 2 p.93 ~ p.98
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Effects of Ginseng Total Saponins on the Analgesia and Tolerance Development of Pentazocine
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김학성
안성희/성연희/김선혜/오기완
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Abstract
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This study examined the influence of ginseng total saponins (GTS) on the analgestic action and tolerance development of pentazocine in mice. Pentazocine prolonged the latency to response in the tail flick rather in the tail pinch test. The
analgesic
effect of pentazocine as antagonized by naloxone and completely eliminated by pretreatment with p-chlorphenylalanine(pCPA). GTS prevented the pentazocine-incuced analgesia and inhibited the development of tolerance to pentazocine. The
antagonistic
effect of GTS on the pentazocine-induced analgesia was abolished by 5-HTP. But not by L-DOPA. These results suggest that GTS inhibits the analgesic action of pentazocine by the interaction with serotonergic neuron
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KEYWORD
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